Eri Clinic Omotesando

Eri Clinic Omotesando
Stem cell therapy from autologous fat

Super advanced stem cells / Advanced treatment

Stem cell therapy from autologous fat

Super advanced stem cells / Advanced treatment

Stem cell therapy from autologous fat

Stem cell therapy from autologous fat?

Stem cells are extracted from the patient’s own fat and are cultured to enrich the “stem cells” and “cytokines *1” secreted from the stem cells.
It is a treatment that brings stem cells and cytokines that have been regenerated into the body by infusion or injection.
Fat-derived stem cells are able to differentiate into internal organs other than fat cells such as the digestive tract, muscles and bones, and are expected to repair damaged or aging cells.
In addition, cytokines released from stem cells directly affect the surrounding cells and may have various therapeutic effects such as controlling the immune system, angiogenesis, anti-inflammatory, antioxidant, Anti-apoptosis, tissue repair …

*1 What are cytokines? … During cell culture, many proteins called “cytokines” are released into the culture medium to activate, grow and proliferate. Cytokine plays an important role in restoring the function of damaged tissues and cells in the body, and can be thought to have the effect of restoring cells lost due to aging.

A world-class authority on cancer treatment research and regenerative medicine
Dr.Takahiro Ochiya

Takahiro Ochiya Doctor’s Profile

Professor of Tokyo Medical University / medical doctor
Head of Molecular Cell Therapy Research Department, National Cancer Center Research Institute

Awards, etc.

●February 21, 2020 – The Academic Award of the Princess Takamatsu Cancer Research Foundation has been awarded for the achievement of establishing a method of early diagnosis of cancer by microRNA in body fluids and its practical application.
●January 2020 – Web of science announced the world’s most influential scientific researchers and he was selected in Highly Cited Researchers in 2019.
●In September 2017, he was the only candidate in Japan chosen by the Nobel Committee to be one of the 10 most notable researchers in the world and invited to give a special lecture.

For more details about doctor’s profile, please click here

About Doctor Takahiro Ochiya
Director Eri Katagiri

Doctor Ochiya has partnered with us as an advisor to support “Regenerative Medicine Stem cell therapy” and “Super Premium Immunotherapy” to prevent cancer provided by Eri Clinic Omotesando.

Why Eri Clinic Omotesando is an aptitude medical institution

The reason our institute is an appropriate medical facility

Officially received a license to provide regenerative medicine from the Department of Health and Labor.
A team of plastic surgery professors from Keio University Hospital will be in charge of collecting adipose tissue.
With our highly skilled doctors, we will provide safe treatment with little burden for the patient.
Collaborating with the cell manufacturing facility (FA3190002) to apply the method of ensuring the safety of regenerative medicine by holding the highest culture and safety techniques in Japan.

Characteristics of fat-derived stem cell therapy

自己脂肪由来幹細胞治療の特徴

①High cell content

The number of MSCs derived from the fat contained in adipose tissue is 500 times the amount of MSC※2 contained in bone marrow (1). The amount of MSC derived from bone marrow is limited when collected, but the amount of MSC derived from fat can be collected from whole body fat tissue.

②Producing large amounts of growth factors (cytokines)

Fat-derived MSCs produce many growth factors (regenerative factors) such as HGF (hepatocellular growth factor) and VEGF (vascular endothelial growth factor) that contribute to repair. The internal organs are better than elements derived from bone marrow (2).

③Cultivation is possible even for the elderly

The number of MSC decreases with age. Not only is it affected by aging, but it has also been reported that the growth rate of bone marrow MSCs decreases with the rate of aging (3).
In contrast, fat-derived MSCs can develop without problems, even from old adipose tissue.

④Causing less burden for patients

Because adipose tissue is located close to the surface of the body, there is less burden on the patient during collection.

※2 ※ What are mesenchymal stem cells (MSC)? …Mesenchymal stem cells are one of the human stem cells and are also known as MSC.MSCs are found throughout the body, including bone marrow, fat and skin. In addition, the nature of MSC varies slightly depending on the location. Although MSC was originally defined as cells that can differentiate into fat, bone and cartilage, they can also differentiate into a number of other tissue cells (liver, nerve, etc)

References

(1) Ohgushi H, Caplan AI. Stem cell technology and boice-ramics: from cell to gene engineering. J Biomed Mater Res. 1999;48(6):913-27.
(2) Iwashima S, Ozaki T et al. Novel culture system of mesenchymal stromal cells from human subcutaneous adipose tissue. Stem Cells Dev. 2009 May;18(4):533-43.
(3) Mareschi K, Ferrero I et al. Expansion of mesenchymal stem cells isolated from pediatric and adult donor bone marrow. J Cell Biochem. 2006 Mar 1;97(4):744-54.

The effectiveness of treatment by stem cells derived from autologous fat

Controlling the immune system: Regulate and suppress the immune system. It is expected to be effective against allergies like atopic dermatitis and autoimmune diseases like rheumatoid arthritis.

Increasing blood vessels: Create new blood vessels to improve blood circulation. It may be effective for arteriosclerosis.

Anti-inflammatory effects: It inhibits inflammation in the body, and is expected to have an anti-aging effect on arthritis, skin and blood vessels.

Anti-oxidant: Reduce active oxygen and prevent cell aging.

Effective repair institutions: Helps repair and regenerate damaged or dysfunctional tissues.

Preventing cell death: Prevent apoptosis, a form of cell death.

About the disadvantages of stem cell therapy

①Because the medical technology is so modern, there is little evidence from randomized comparative trials (RCTs).
②The pathological relationship and effectiveness of treatment have not been clear, but there have been reports of a case of pulmonary embolism in the past.
* At our job, the treatment is closely monitored and maximized safety.

The procedure for treatment with stem cells from autologous fat

細胞培養土による細胞処理・CPCの様子

治療サイクル

① First examination　The doctor will advise, explain the treatment as well as fill out the consent form for treatment.After careful review, the customer who wants treatment will fill in the consent form.
Qualified tests (primarily blood tests) will be performed before treatment.
② Sampling　Local anesthetist and fat sample from patient (about 10 g)
In addition, we will also draw blood for use in cell culture (60 ml)
③ Cell culture　Cultivation takes about 3-4 weeks at the cell processing facility with the highest standards of culture technology and safety.We will notify you of the treatment schedule after completion of culture.
④ Bringing back to the body　Giving back to the body by infusion
Example: About 50 – 200 million stem cells in 1 ml *
⑤ Tracking　Visit and monitor about 60 days after the first dose.

■Stem cell therapy from autologous fat Optional：culture supernatant (※It is possible to be created and cultured once only)

It refers to the cytokines and growth factors that are produced when mesenchymal stem cells are cultured. It is highly effective in promoting tissue repair and regeneration.

Optional
culture supernatant (※It is possible to be created and cultured once only)

※The number of cells to be administered is limited to a maximum of 200 million cells per dose.
※Culture fees are listed as a rough guide for gross profit calculation. Various blood tests for the first time and after the second year, freezing and storage fees will be charged.

1 Patients with positive test results for infectious diseases (HCV, HBV, HIV, HTLV-1, syphilis serodiagnosis)
2 Patients who have allergic reactions to local anesthetics, penicillin used during culture, streptomycin, and amphotericin B.
3 Patients with severe cardiac, hematological, pulmonary, renal, or hepatic diseases, brain diseases, psychiatric diseases, malignant tumors, or diabetes.
4 Patients with severe organ damage, such as severe diabetes (HbA1c 7.0% or higher), severe heart failure, or renal failure (creatinine clearance less than 30 ml/min).
5 under 20 years old or over 80 years old.
6 pregnant women and nursing mothers.
7 If the person does not have normal capacity to consent, or if consent cannot be obtained from a substitute.
8 The patient has not received a consent explanation document regarding this treatment, has received sufficient explanation, and has not given free and voluntary consent in writing (Substitute has not given written consent).
9 When the doctor judges that the patient is not suitable for the treatment based on medical interview and examination.

Stem cell culture supernatant therapy from autologous fat

Method of administration：Drip infusion / Iontophoresis / Mesotherapy / Nebulizer / Solution / Nasal spray

Method of administration
■Drip infusion By injecting the active ingredients directly into the blood vessels, the active ingredients can act directly on the body. 。
■Iontophoresis It is a method of delivering active ingredients deep into the skin by applying a weak electric current.
■Mesotherapy It is a method of delivering active ingredients directly to the subcutaneous area by topical injection into the skin or scalp for quick results.
■Nebulizer The new nebulizer contains Dr. Eri’s original formulation, which is a mixture of 2 vials of deciduous autologous adipose-derived stem cell culture medium solution at a high concentration, plus” α-lipoic acid “, which is a high antioxidant component.
■Solution (Home care） This is a way to use undiluted deciduous autologous adipose-derived stem cell culture medium solution as a home care product.
■Nasal spray (Home care） The new nasal spray contains Dr. Eri’s original formulation, which is a mixture of 2 vials of deciduous autologous adipose-derived stem cell ulture medium solution at a high concentration, plus” α-lipoic acid “, which is a high antioxidant component.

Question

Q．What is the difference from PRP (platelet rich plasma) therapy?

PRP is a treatment that is obtained by dissociation of blood, not by culture. So, unlike stem cell therapy, it contains few growth factors and cytokines, and stimulating effect on cells cannot be expected. （There are also reports of risk of skin problems such as inflammation）

Super advanced stem cells / Advanced treatment

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