Immunity is thought to decrease with age, thereby increasing the risk of developing various diseases, such as viral infections and cancer.
” Superior immunotherapy / therapy ” is a treatment that is expected to have anti-cancer effects by strengthening the artificial immune system. The patient’s own immune cells are cultured and processed outside of the body, activated and returned to the patient’s body for treatment.
This treatment is used in clinical practice as a systemic treatment that can be performed while maintaining the patient’s quality of life (QOL). Because you use your own cells, there’s almost no elimination or side effects, so you can rest assured.
The Eri Omotesando Clinic focused on NK cell immunotherapy * and other therapies using different immune cells. As an experienced and knowledgeable doctor, Dr. Eri Katagiri has partnered with a reliable laboratory with advanced cell culture treatment technology to ensure patients can be assured of treatment. We will provide you with the most advanced treatments.
A world-class authority on cancer treatment research and regenerative medicine Dr.Takahiro Ochiya
Takahiro OchiyaDoctor’s Profile
Professor of Tokyo Medical University / medical doctor
Head of Molecular Cell Therapy Research Department, National Cancer Center Research Institute
Awards, etc.
●February 21, 2020 – The Academic Award of the Princess Takamatsu Cancer Research Foundation has been awarded for the achievement of establishing a method of early diagnosis of cancer by microRNA in body fluids and its practical application.
●January 2020 – Web of science announced the world’s most influential scientific researchers and he was selected in Highly Cited Researchers in 2019.
●In September 2017, he was the only candidate in Japan chosen by the Nobel Committee to be one of the 10 most notable researchers in the world and invited to give a special lecture.
Maybe “Individualized treatment” is suitable for each patient
Just like people have different faces, the nature of cancer varies from patient to patient. On the other hand, there are many types of immune cells that attack cancer, and there are many types of immune therapies (immune cell therapies) depending on which cells are used for treatment.
There are many treatments available at our institute depending on the type of immune cell used, such as NK cells, Tβ cells, T cells and dendritic cells (type of immunotherapy ). By examining the status of cancer and immune cells through counseling and suggesting appropriate treatment, we have established a system that can provide “personalized treatment” for As many patients as possible.
Immunotherapy・Therapy example
Those who want to improve immunity and prevent cancer
Compliance with the new law “Ensuring safety in regenerative medicine” with the highest culture and safety technology in Japan. Business alliance with special cell handling facilities (FA3150001)
Director Katagiri, a physician with extensive experience and knowledge, can provide advanced treatment, based on the patient’s physical conditions.
Preventing cancer by immunotherapy
Cancer arises due to gene damage caused by eating, smoking, viruses, bacteria, radiation, ultraviolet rays, oxygen activity, chemicals …
Immunity plays an important role in preventing the development of cancer.
For example, low NK activity in the blood can increase the risk of cancer.
However, the activity of NK cells is decreasing with age. Therefore,” immunotherapy / therapy ” enhances the ability of self-healing by maximizing activation of immunity. , as well as health promotion.
It is highly effective in treating and preventing cancer.
Immunotherapy is gaining attention as a “safe and ideal” treatment.
Characteristics of immunotherapy
①Less side effects by using individual cells.
Immunotherapy (immune cell therapy) uses the patient’s own immune cells for treatment, so there are very few side effects except for the possibility of a low fever and minimal burden on the body.Because of the minimal side effects, it is possible to continue treatment while maintaining QOL (quality of life) without losing physical strength.
②Can be used along with other treatments, and can expect a combined effect.
Immunotherapy (immune cell therapy) may be used along with other therapies, and can expect a combined effect.
Recent studies have shown that increasing systemic immunity by immunotherapy (immune cell therapy) can improve the overall therapeutic effect without affecting the effects of various methods. For this reason, it is also expected to be a treatment that should underlie the three main treatments for cancer (surgery, radiation and chemotherapy).
③Outpatient treatment, without hospitalization.
The treatment is basically a repeat of blood and fluid transfusion every 2 to 3 weeks, so no hospitalization and treatment can be done on an outpatient basis.
④Can be consulted from early stage to advanced cancer.
Immunotherapy (immune cell therapy) is a body-friendly treatment, using the body’s own cells, so it is not only used for patients in the early stages but also for advanced and recurrent cancers.
In addition, it can be applied to most types of cancer except for some blood cancers
* Because this therapy varies depending on the type of treatment, please contact us for details.
How immune cell therapy works
Immune cells are removed from the body by blood collection, proliferation and activation by cellular processing and back to the body again. Then repeat this cycle several times.
Effective as a treatment to prevent relapses
Immunotherapy (immune cell therapy) may also be appropriate to prevent recurrence. As a treatment to prevent recurrence after surgery, immune cell therapy is expected to prevent recurrence without having to worry about side effects.
* The use of postoperative immune cell therapy has reduced relapse and increased survival, as reported in prestigious journals abroad.（Cancer Immunol Immunother（2014）、Lancet（2000）、Cancer（1997））(※)
(※)・『Cancer Immunol Immunother』 Kimura H, Matsui Y, Ishikawa A, Nakajima T, Yoshino M, Sakairi Y.Randomized controlled phase III trial of adjuvant chemo-immunotherapy with activated killer T cells and dendritic cells in patients with r esected primary lung cancer. Cancer Immunol Immunother. Epub 20 14 Sep 28.
・『Lancet』 Takayama T, Sekine T, Makuuchi M, Yamasaki S, Kosuge T, Yamamoto J, Shimada K, Sakamoto M, Hirohashi S, Ohashi Y, Kakizoe T., Adoptive immunotherapy to lower postsurgical recurrence rates of hepatoc ellular carcinoma: a randomised trial., Lancet. 356(9232):802-7, 2000.
・『Cancer』 Kimura H, Yamaguchi Y., A phase III randomized study of interleukin-2 lymphokine-activated killer cell immunotherapy combined with chemotherapy or radiotherapy after curative or noncurative resection of primary lung carcinoma. Cancer. 80(1):42-9, 1997
Types of immune cells and treatments
NK cell therapy
NK cell Get rid of cancer as soon as it is detected
Always patrol the body, launching and destroying cancer cells when they are found. This is a method of stimulating immune cells, mainly NK cells, found in peripheral blood with IL-2, and activating, proliferating and returning them to the body.
Alpha cell therapy and beta T（αβ T-cell therapy）
αβT cells Loyal work
Can kill cancer cells with antigens . This is a treatment in which peripheral blood mononuclear cells are grown in the presence of anti-CD3 and IL-2 antibodies, and T cells are stimulated to activate and proliferate. αBT cells and bring them back to the body.
Gamma delta T cell therapy(T-cell therapy)
γδT cell Remove cancer with anti-cancer effect
Removing cancer cells with strong anti-cancer effect and hiding antigen. This treatment involves culture of Y6T cells, contained in peripheral blood about 2% in the presence of zoledronic acid and IL-2, to selectively activate, proliferate and return Y5T cells the body.
Dendritic cell vaccine therapy
Dendritic cell Get the information of the enemy and get in touch with the target
Also known as antigen-presenting cells, they are like gatekeepers. A cell quickly finds an antigen, transmits that information to helper T cells and turns on the immune response. This is a method in which dendritic cells differentiate mononuclear cells in peripheral blood that are loaded with target cancer cells and returned to the body. This is a treatment that is expected that the dendritic cells are inserted that will lead to the development of antigens in the body, thereby attracting cancer-specific CTL.
About side effects
Immune cell therapy is basically treated by collecting and managing blood, allowing outpatient visits. Although a mild fever may occur, the safety is high and the side effects are negligible.（1） ※（1） Kamigaki T. et al., Anticance「Res. 2014: 34 (8): 4601-7」
Treatment process
① Advice The doctor advises, explains the treatment, the customer signs the consent form for treatment.
② Blood sampling First sampling
The number and method of taking blood varies depending on the type of treatment, and there are two methods: taking a blood by syringe and apheresis (component blood sampling), a method that only collects the necessary components while the blood still circulating outside the body.
③ Cell culture Culture for about 2 to 3 weeks
(The number of culture days varies depending on the cell type)
④ Drip lnfusion or lnjection culture and activation of immune cells
Location: intravascular or subcutaneous / intradermal.
⑤ Follow up Follow up and monitor about 2 to 3 weeks after the first medication
⑥ Treatment In principle, the course consists of 6 sessions taken every 2 to 3 weeks.
※ Before starting treatment, a fee is required. Contact us for more information.
